产品中心
当前位置：首页>产品中心Anti-GPR18/PE-Cy7
货号： bs-12015R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12015R-PE-Cy7
- 英文名称
- Anti-GPR18/PE-Cy7
- 中文名称
- PE-Cy7标记的G蛋白偶联受体18抗体
- 别 名
- G protein coupled receptor 18; G-protein coupled receptor 18GPCRW; GPR 18; GPR18; N arachidonyl glycine receptor; NAGly receptor; GPR18_HUMAN; GPCR18.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human G protein coupled receptor 18
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR18 (G protein-coupled receptor 18), also known as GPCRW, is a 331 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor family. Expressed abundantly in spleen and testis, GPR18 functions as a receptor for N-arachidonyl glycine and is thought to contribute to the regulation of the immune system. GPR18 activity is mediated by G proteins that specifically inhibit adenylyl cyclase.
Function:
G protein coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. GPCR GPR18 is a member of this family and has been reported to be expressed at high levels in testis and spleen and at lower levels in other tissues associated with endocrine and immunologic/hematologic functions. It is thought to be a receptor for N arachidonyl glycine. It may contribute to regulation of the immune system.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 2841 Human
Entrez Gene: 110168 Mouse
Entrez Gene: 679957 Rat
Omim: 602042 Human
SwissProt: Q14330 Human
SwissProt: Q8K1Z6 Mouse
SwissProt: A1A5S3 Rat
Unigene: 741589 Human
Unigene: 37405 Mouse
Unigene: 205907 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.