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货号： bs-11980R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11980R-PE-Cy7
- 英文名称
- Anti-CABP4/PE-Cy7
- 中文名称
- PE-Cy7标记的瞬时受体电位通道蛋白4抗体
- 别 名
- CABP 4; CaBP4; CABP4_HUMAN; Calcium binding protein 4; Calcium-binding protein 4; CSNB 2B; CSNB2B.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 通道蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 111kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TRPC5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The calcium binding protein (CaBP) family shares much similarity to calmodulin. It has been shown that CaBP proteins can substitute functionally for, and probably augment the function of, calmodulin. Calcium binding proteins are a crucial part of calcium mediated cellular signal transduction in the central nervous system. There are several members of the family with varying expression patterns. CaBP1 and CaBP2 can be expressed as multiple, alternatively spliced variants in brain and retina. CaBP3, CaBP4 and CaBP 5 are restricted to retinal rod and cone cells.
Function:
Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages.
Subcellular Location:
Cytoplasm. Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.Target information above from: UniProt accession P57796 The UniProt ConsortiumThe Universal Protein Resource (UniProt) in 2010Nucleic Acids Res. 38:D142-D148 (2010). Information by UniProt
Tissue Specificity:
Expressed in retina and in the inner hair cells (IHC) of the cochlea.
Post-translational modifications:
Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity.
DISEASE:
Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B) [MIM:610427]. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.
Similarity:
Contains 4 EF-hand domains.
Database links:Entrez Gene: 57010 Human
Entrez Gene: 73660 Mouse
Entrez Gene: 365394 Rat
Omim: 608965 Human
SwissProt: P57796 Human
SwissProt: Q8VHC5 Mouse
Unigene: 143036 Human
Unigene: 379226 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.