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货号： bs-11953R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11953R-PE-Cy7
- 英文名称
- Anti-SLC25A12/PE-Cy7
- 中文名称
- PE-Cy7标记的钙结合线粒体载体蛋白抗体
- 别 名
- AGC1; Araceli hiperlarga; ARALAR; ARALAR1; Calcium binding mitochondrial carrier superfamily member; Calcium-binding mitochondrial carrier protein Aralar1; CMC1_HUMAN; Mitochondrial aspartate glutamate carrier 1; SLC25A12; Solute carrier family 25 member 12; solute carrier family 25, member 12.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 细胞类型标志物 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 75kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SLC25A12/ARALAR
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
Function:
Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle.
Subcellular Location:
Mitochondrion inner membrane.
Tissue Specificity:
High levels in heart and skeletal muscle, low in brain and very low in kidney.
DISEASE:
Defects in SLC25A12 are the cause of aspartate-glutamate carrier 1 deficiency (AGC1D) [MIM:612949]; also called global cerebral hypomyelination. This syndrome consists of a child severe psychomotor retardation, hypotonia and hypomyelination of the central nervous system.
Similarity:
Belongs to the mitochondrial carrier family.
Contains 4 EF-hand domains.
Contains 3 Solcar repeats.
Database links:Entrez Gene: 8604Human
Entrez Gene: 78830Mouse
Entrez Gene: 362145Rat
Omim: 603667Human
SwissProt: O75746Human
SwissProt: Q8BH59Mouse
Unigene: 470608Human
Unigene: 30928Mouse
Unigene: 483680Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.