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货号： bs-11926R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11926R-PE-Cy7
- 英文名称
- Anti-PNMA1/PE-Cy7
- 中文名称
- PE-Cy7标记的旁瘤抗原MA1抗体
- 别 名
- 37 kDa neuronal protein; MA1; Paraneoplastic antigen MA1; Neuron- and testis-specific protein 1; Paraneoplastic antigen Ma1; Pnma1; PNMA1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PNMA1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Paraneoplastic neurological disorders (PNDs) are rare syndromes that are caused by, or associated with, an underlying neoplasm. The most common neoplasm among young male patients is testicular cancer, but the leading cause among other patients is lung cancer. Most PNDs are caused by an immune response against onconeural antigens, causing progressive neurological damage. The paraneoplastic antigen MA family contains three known members: MA1, MA2 and MA3. MA1, also designated neuron- and testis-specific protein 1, is a nucleolar protein in normal cells but localizes to the cytoplasm of tumor cells. MA2, also designated onconeuronal antigen MA2, is a nucleolar protein expressed in brain and testis. MA3 is highly expressed in brain and testis and is expressed at low levels in heart, trachea and kidney.
Function:
PNMA1 (Paraneoplastic antigen MA1) is a protein that is highly restricted to the brain and testis. A paraneoplastic phenomenon is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. These phenomena are mediated by humoral factors (by hormones or cytokines) excreted by tumor cells or by an immune response against the tumor. Sometimes the symptoms of paraneoplastic syndromes show even before the diagnosis of a malignancy. Paraneoplastic syndromes can be divided into 4 main categories: mucocutane paraneoplastic syndromes, neurological paraneoplastic syndromes, haematological paraneoplastic syndromes and endocrine metabolic syndromes.
Subcellular Location:
Nucleus; nucleolus. In tumor cells, it is cytoplasmic.
Tissue Specificity:
Testis and brain specific. In some patients suffering from cancers, it is also specifically expressed by the paraneoplastic tumor cells.
Similarity:
Belongs to the PNMA family.
Database links:Entrez Gene: 538718 Cow
Entrez Gene: 490774 Dog
Entrez Gene: 100050444 Horse
Entrez Gene: 9240 Human
Entrez Gene: 70481 Mouse
Entrez Gene: 100154070 Pig
Entrez Gene: 170636 Rat
Omim: 604010 Human
SwissProt: A6QLK5 Cow
SwissProt: Q8ND90 Human
SwissProt: Q8C1C8 Mouse
SwissProt: Q8VHZ4 Rat
Unigene: 194709 Human
Unigene: 444348. Mouse
Unigene: 81186 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.