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货号： bs-11947R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11947R-PE-Cy7
- 英文名称
- Anti-POU3F3/PE-Cy7
- 中文名称
- PE-Cy7标记的大脑蛋白1抗体
- 别 名
- Brain 1; Brain1; Brain specific homeobox/POU domain protein 1; Brain-1; Brain-specific homeobox/POU domain protein 1; Brain1; BRN 1; Brn-1; BRN1; class 3; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8; OTF 8; OTF-8; OTF8; PO3 F3; PO3F 3; PO3F3; PO3F3_HUMAN; POU class 3 homeobox 3; POU domain; POU domain, class 3, transcription factor 3; POU3 F3; POU3F 3; Pou3f3; RHS 1; Rhs 2; RHS1; Rhs2; Skin 1; Skin1; transcription factor 3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 神经生物学 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Brain1/POU3F3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU domain proteins. Expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons, Brn-1 and Brn-2 appear to critically control the initiation of radial migration of cortical neurons. Brn-2 is thought to be involved in smooth muscle cell development and differentiation. Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. Brn-3a has two functional transactivating domains, one at the amino terminus and one at the carboxy terminus. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor.
Function:
Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5-ATTTGCAT-3).
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain.
Similarity:
Belongs to the POU transcription factor family. Class-3 subfamily.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.
Database links:Entrez Gene: 5455Human
Entrez Gene: 18993Mouse
Entrez Gene: 192109Rat
Omim: 602480Human
SwissProt: P20264Human
SwissProt: P31361Mouse
SwissProt: Q63262Rat
Unigene: 673855Human
Unigene: 440553Mouse
Unigene: 483029Mouse
Unigene: 11354Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.