产品中心
当前位置：首页>产品中心Anti-Gbx2/PE-Cy7
货号： bs-11849R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11849R-PE-Cy7
- 英文名称
- Anti-Gbx2/PE-Cy7
- 中文名称
- PE-Cy7标记的肠和大脑特定同源蛋白2抗体
- 别 名
- Gastrulation and brain-specific homeobox protein 2; Gastrulation brain homeo box 2 ; Gastrulation brain homeo box 2; gbx2; GBX2_HUMAN; Homeobox protein GBX 2 ; Homeobox protein GBX 2; Homeobox protein GBX-2; Homeobox protein STRA7; Mmoxa.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 发育生物学 神经生物学 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 37kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Gbx2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes Gbx2 and Otx2. Gbx2 and Otx2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, Gbx2 negatively regulates Otx2 expression along the anterior-posterior axis; Gbx2(-) mutants demonstrate an expanded Otx2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. Gbx2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is over-expressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of Gbx2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that Gbx2 expression may be required for growth of malignant prostate cells.
Function:
May act as a transcription factor for cell pluripotency and differentiation in the embryo.
Subunit:
May act as a transcription factor for cell pluripotency and differentiation in the embryo.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 homeobox DNA-binding domain.
Database links:Entrez Gene: 486174 Dog
Entrez Gene: 2637 Human
Entrez Gene: 14472 Mouse
Omim: 601135 Human
SwissProt: P52951 Human
SwissProt: P48031 Mouse
Unigene: 184945 Human
Unigene: 204730 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.