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货号： bs-11818R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11818R-PE-Cy7
- 英文名称
- Anti-CELSR2/PE-Cy7
- 中文名称
- PE-Cy7标记的表皮生长因子样蛋白2抗体
- 别 名
- Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; CDHF10; CELR2_HUMAN; Celsr2; EGF like domain multiple 2; EGF-like protein 2; EGFL2; epidermal growth factor like 2; Epidermal growth factor-like protein 2; Flamingo homolog 3; Flamingo1; KIAA0279; MEGF3; Multiple EGF-like domains protein 3; Multiple epidermal growth factor-like domains protein 3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 信号转导 通道蛋白 细胞膜受体 G蛋白偶联受体 细胞骨架 细胞外基质 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 314kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CELSR2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons.
Function:
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Highest expression in brain and testis.
Post-translational modifications:
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains
Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 9 cadherin domains.
Contains 7 EGF-like domains.
Contains 1 GPS domain.
Contains 1 laminin EGF-like domain.
Contains 2 laminin G-like domains.
Database links:Entrez Gene: 100061311 Horse
Entrez Gene: 1952 Human
Entrez Gene: 53883 Mouse
Entrez Gene: 83465 Rat
Omim: 604265 Human
SwissProt: Q9HCU4 Human
SwissProt: Q9R0M0 Mouse
SwissProt: Q9QYP2 Rat
Unigene: 57652 Human
Unigene: 39728 Mouse
Unigene: 222746 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.