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货号： bs-0299R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0299R-PE-Cy7
- 英文名称
- Anti-Adenylate Kinase 1/PE-Cy7
- 中文名称
- PE-Cy7标记的腺苷酸激酶-1抗体
- 别 名
- Adenylate kinase isoenzyme 1; Adenylate kinase soluble; AK 1; AK1; AK-1; ATP AMP transphosphorylase; Myokinase; KAD1_HUMAN; ATP-AMP transphosphorylase 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 信号转导 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Goat, Monkey,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 21kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Adenylate Kinase 1 (131-194aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008].
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
DISEASE:
Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631].
Similarity:
Belongs to the adenylate kinase family.
Database links:Entrez Gene: 203 Human
Entrez Gene: 11636 Mouse
Entrez Gene: 24183 Rat
Omim: 103000 Human
SwissProt: P00568 Human
SwissProt: Q9R0Y5 Mouse
SwissProt: P39069 Rat
Unigene: 175473 Human
Unigene: 29189 Mouse
Unigene: 79537 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AK1存在于人类红细胞上及某些组织中的具有遗传多态性的同工酶, 腺苷酸激酶催化 ATP，AMP 和 ADP 的转化，它是维持各种腺苷酸平衡的关键酶。因此，腺苷酸激酶就成为调控腺苷酸库大小的靶标分子。