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货号： bs-1087R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1087R-PE-Cy7
- 英文名称
- Anti-Angiopoietin 4/PE-Cy7
- 中文名称
- PE-Cy7标记的血管生成素3/血管生成素4抗体
- 别 名
- Angiopoietin 4; AGP4; ANG3; ANG-4; ANG 4; ANGPT4; AGP4; ANGP4_HUMAN.ANG 3; ANG-3; ANG3; Angioarrestin; Angiopoietin 3; Angiopoietin like 1; Angiopoietin like protein 1; Angiopoietin related protein 1; Angiopoietin Y1; Angiopoietin-3; Angiopoietin-like protein 1; Angiopoietin-related protein 1; ANGL1_HUMAN; ANGPT3; ANGPTL1; AngY; ARP1; dJ595C2.2; KIAA0351; UNQ162.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 54kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ANGPT4 C-terminus
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Angiopoietin 4 is a glycosylated protein with a fibrinogen C terminal domain. It is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators.
Angiopoietin 4 is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. It may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described
Function:
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Subunit:
Homodimer; disulfide-linked. Interacts with TEK/TIE2.
Subcellular Location:
Secreted (Probable).
Tissue Specificity:
Highly expressed in the lung with much lower levels found in other tissues.
Similarity:
Contains 1 fibrinogen C-terminal domain.
Database links:Entrez Gene: 51378Human
Omim: 603705Human
SwissProt: Q9Y264Human
Unigene: 278973Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血管生成素4-ANGPTL4与小血管生成、肿瘤的转移有很重要的关系。