产品中心
当前位置：首页>产品中心Anti-Aquaporin 4 /PE-Cy7
货号： bs-0634R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0634R-PE-Cy7
- 英文名称
- Anti-Aquaporin 4 /PE-Cy7
- 中文名称
- PE-Cy7标记的水通道蛋白4抗体
- 别 名
- aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 信号转导 通道蛋白 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
- 产品应用
- Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human AQP4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
Subunit:
Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Brain, muscle, heart, kidney, lung, and trachea.
Similarity:
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Database links:Entrez Gene: 281008Cow
Entrez Gene: 361Human
Entrez Gene: 11829Mouse
Entrez Gene: 25293Rat
Omim: 600308Human
SwissProt: O77750Cow
SwissProt: P55087Human
SwissProt: P55088Mouse
SwissProt: P47863Rat
Unigene: 281008Cow
Unigene: 315369Human
Unigene: 250786Mouse
Unigene: 90091Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
通道蛋白（Channel Protein）
水通道蛋白(AQPs)广泛分布于机体不同组织器官中,脑组织中的水通道蛋白主要为AQP4.
AQP-4蛋白主要在星型胶质细胞和室管膜细胞内表达,尤其在于毛细血管和软脑膜直接接触的胶质细胞上及血管周表达丰富.
水通道蛋白4的分布特点与其功能密切相关,可能是脑脊液重吸收、渗透压调节、脑水肿形成等生理、病理过程的分子生物学基础.研究水通道蛋白4可为脑水肿及水代谢疾病提供分子水平的理论依据,同时为临床治疗脑水肿及水代谢疾病提供一种新途径.