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货号： bs-0275R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0275R-PE-Cy7
- 英文名称
- Anti-Bassoon/PE-Cy7
- 中文名称
- PE-Cy7标记的锌指蛋白231抗体
- 别 名
- Bassoon; BSN; KIAA0434; Neuronal double zinc finger protein; Presynaptic cytomatrix protein; Protein bassoon; Zinc finger protein 231; ZNF 231; ZNF231; Neuronal double zinc finger protein; Zinc-finger protein 231; BSN_HUMAN; ZNF 231.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 锌指蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 432kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BSN (2901-3000aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008].
Function:
Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses.
Subunit:
Interacts with ERC2/CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN.
Subcellular Location:
Cytoplasm. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density.
Tissue Specificity:
Exclusively expressed in brain.
Post-translational modifications:
Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization.
Database links:Entrez Gene: 8927 Human
Entrez Gene: 12217 Mouse
Entrez Gene: 29138 Rat
Omim: 604020 Human
SwissProt: O43161 Human
SwissProt: Q9UPA5 Human
SwissProt: O88737 Mouse
SwissProt: O88778 Rat
Unigene: 194684 Human
Unigene: 20425 Mouse
Unigene: 29999 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白是80年代中期发现的一类DNA结合蛋白，在真核生物中,锌指蛋白可能是最大的一类DNA结合蛋白，并且由锌指蛋白调控基因表达是发育和其他过程的一个非常普遍的现象。在最近的几年中，发现某些锌指蛋白对肌肉的发育具有重要的调节作用。