产品中心
当前位置：首页>产品中心Anti-CNPase/PE-Cy7
货号： bs-1000R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1000R-PE-Cy7
- 英文名称
- Anti-CNPase/PE-Cy7
- 中文名称
- PE-Cy7标记的2’,3’-环腺苷酸-3’-磷酸二酯酶抗体
- 别 名
- 2,3-cyclic-nucleotide 3-phosphodiesterase; CNPase; Cnp; Cnp-1; Cnp1; 2; 23 cyclic nucleotide 3 phosphodiesterase; 23-cyclic-nucleotide 3-phosphodiesterase; 3-cyclic-nucleotide 3-phosphodiesterase; CN37_HUMAN; CNP 1; CNP; CNP1; CNPase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
- 产品应用
- Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 48kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CNPase
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
2,3-cyclic nucleotide 3-phosphodiesterase (CNP or CNPase). This family consists of the eukaryotic protein 2,3-cyclic nucleotide 3-phosphodiesterase (CNP). 2,3-cyclic nucleotide 3-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2,3-cyclic nucleotides to produce 2-nucleotides in vitro. Although physiologically relevant substrates with 2,3-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2,3-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterised by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2,3 phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.
Function:
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Subunit:
Exists as monomers and homodimers.
Subcellular Location:
Membrane. Melanosome. Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity:
Belongs to the cyclic nucleotide phosphodiesterase family.
Database links:Entrez Gene: 280752Cow
Entrez Gene: 607694Dog
Entrez Gene: 1267Human
Entrez Gene: 12799Mouse
Entrez Gene: 493772Pig
Entrez Gene: 25275Rat
Omim: 123830Human
SwissProt: P06623Cow
SwissProt: P09543Human
SwissProt: P16330Mouse
SwissProt: P18104Pig
SwissProt: P13233Rat
SwissProt: P56283Sheep
Unigene: 273621Human
Unigene: 15711Mouse
Unigene: 31762Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.