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货号： bs-1012R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1012R-PE-Cy7
- 英文名称
- Anti-BMP2/PE-Cy7
- 中文名称
- PE-Cy7标记的骨形态发生蛋白2抗体
- 别 名
- bone morphogenetic protein 2; BMP 2; BMP 2A; BMP2; BMP2A; BMP-2; BMP2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 发育生物学 神经生物学 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 13/44kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BMP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis.
Function:
Induces cartilage and bone formation.
Subunit:
Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN.
Subcellular Location:
Secreted.
Tissue Specificity:
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Similarity:
Belongs to the TGF-beta family.
Database links:Entrez Gene: 650 Human
Entrez Gene: 12156 Mouse
Entrez Gene: 29373 Rat
Omim: 112261 Human
SwissProt: P12643 Human
SwissProt: P21274 Mouse
SwissProt: P49001 Rat
Unigene: 73853 Human
Unigene: 103205 Mouse
Unigene: 90931 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经干细胞标志物
BMP-2主要对未分化间充质细胞和骨系细胞起到募集和分化作用。在骨形成早期，BMP-2不仅可使未分化间质细胞向骨形成中心募集，并分化为骨系细胞，而且可使成纤维细胞、成肌细胞及骨髓的基细胞逆转分化为骨系细胞。其主要过程是：增加或抑制这些细胞内的某些特异性蛋白的分泌，使成纤维细胞分化为成骨细胞，成肌细胞快速分化为肥大的软骨细胞，并促进基质钙化。
对于成骨细胞，BMP-2则可使之维持其特有细胞表型，并诱导成骨细胞标志物的增高，促进细胞外基质钙化。在骨形成后期，BMP-2还作为一种破骨细胞分化因子与其它支持破骨细胞分化因子直接或间接刺激破骨细胞分化，参与骨的重建。