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货号： bs-0124R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0124R-PE-Cy7
- 英文名称
- Anti-Calcitonin receptor/PE-Cy7
- 中文名称
- PE-Cy7标记的降钙素受体抗体
- 别 名
- Calcitonin receptor precursor; Calcr; CRT; CT R; CTR; CTR1; CALCR_MOUSE; CT-R; CALCR_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse Calcitonin receptor
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Function:
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Subunit:
Interacts with GPRASP2.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
Database links:Entrez Gene: 799 Human
Entrez Gene: 12311 Mouse
Entrez Gene: 116506 Rat
Omim: 114131 Human
SwissProt: P30988 Human
SwissProt: Q60755 Mouse
SwissProt: P32214 Rat
Unigene: 489127 Human
Unigene: 4642 Mouse
Unigene: 10062 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
降钙素受体（Calcitonin receptor,CT-R)是G蛋白偶联受体，有两种受体亚型，CT-R可与多种配体结合，如CGRP、Amylin、Am等。CT-R在破骨细胞中含量最高，也存在于肾等多种器官组织内。