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货号： bs-0352R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0352R-PE-Cy7
- 英文名称
- Anti-DLX4/PE-Cy7
- 中文名称
- PE-Cy7标记的DLX4抗体
- 别 名
- Beta protein 1; distal-less homeobox 4; DLX4; DLX4_HUMAN; DLX7; DLX8; Homeobox protein DLX-4; Homeobox protein DLX-7; Homeobox protein DLX-8; Homeobox protein DLX4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 染色质和核信号 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 26kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DLX4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008].
Function:
May play a role in determining the production of hemoglobin S. May act as a repressor.
Subcellular Location:
Nucleus (Potential).
Tissue Specificity:
Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.
Similarity:
Belongs to the distal-less homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:Entrez Gene: 1748 Human
Entrez Gene: 13394 Mouse
Entrez Gene: 303469 Rat
Omim: 601911 Human
SwissProt: Q92988 Human
SwissProt: P70436 Mouse
Unigene: 591167 Human
Unigene: 439766 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DLX4基因的表达异常与乳腺癌、结肠癌以及白血病的发生有关.与AML-急性髓系白血病有一定的相关性，DLX4 在急性髓系白血病有高表达，在急性淋巴细胞白血病中无表达，可作为AML的一种分子标志，用于两者的鉴别参考。