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货号： bs-0168R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0168R-PE-Cy7
- 英文名称
- Anti-GFRA4/PE-Cy7
- 中文名称
- PE-Cy7标记的GDNF家族受体α4抗体 GDNFRα4
- 别 名
- Persephin receptor; GDNF family receptor alpha 4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 通道蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 27kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GFRA4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Function:
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
Subcellular Location:
Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform GFRalpha4c: Secreted.
Tissue Specificity:
Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
Similarity:
Belongs to the GDNFR family.
Database links:Entrez Gene: 64096 Human
SwissProt: Q9GZZ7 Human
Unigene: 302025 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Persephin receptor 是一个新的神经营养因子，属于GDNFR家族，调节GDNF诱导的自动磷酸化和RET受体的活性。他在维持神经系统正常生存中起重要作用。主要表达在正常和恶性甲状腺髓细胞。分子量约为30kDa。