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货号： bs-1185R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1185R-PE-Cy7
- 英文名称
- Anti-TRAF3/PE-Cy7
- 中文名称
- PE-Cy7标记的肿瘤坏死因子受体相关蛋白3抗体
- 别 名
- CAP 1; CAP1; CD40 associated protein 1; CD40 binding protein; CD40 bp; CD40 receptor associated factor 1; CD40bp; CRAF 1; CRAF1; LAP 1; LAP1; LMP1; Trafamn; LMP1 associated protein; MIPT3; TNF receptor associated factor 3; TRAF 3; TRAF3_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 信号转导 细胞凋亡 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 62kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TRAF3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq].
Function:
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Seems to be involved in activation of NF-kappa-B and JNK and in apoptosis. Is regulated by TANK/ITRAF which competes with TNFRSF5/CD40 for binding. Seems to play a role T-cell dependent immune responses (By similarity).
Subunit:
"Homotrimer (Probable). Heteromer with TRAF5. Binds to TNFRSF5/CD40. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF17/BCMA and EDAR, MAP3K5, MAP3K14, and TRAF-interacting protein TRIP and TRAF and TNF receptor associated protein TTRAP. Binds to TANK/ITRAF and TRAF3IP1. Interacts with TICAM1. Interacts with OTUD5.
Tissue Specificity:
In adult, highest in brain. Also found in kidney, heart, thymus, spleen, lung, muscle, testis and ovary. Not found in liver.
Similarity:
Contains 1 MATH domain.
Contains 1 RING-type zinc finger.
Contains 2 TRAF-type zinc fingers.
Database links:Entrez Gene: 7187Human
Entrez Gene: 22031Mouse
Entrez Gene: 362788Rat
Omim: 601896Human
SwissProt: Q13114Human
SwissProt: Q60803Mouse
Unigene: 510528Human
Unigene: 27431Mouse
Unigene: 12033Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TRAF3是作用最为广泛的一种TRAF蛋白，它可以与LTb R、CD40、TNFRII和LMP1结合，并介导CD30、LMP1活化NF-kB。TRAF3与CD40结合后可以挽救凋亡的B细胞， TRAF3还参与CD40在B细胞中上调CD23的作用。