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货号： bs-0821R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0821R-PE-Cy7
- 英文名称
- Anti-laminin/PE-Cy7
- 中文名称
- PE-Cy7标记的层粘连蛋白抗体
- 别 名
- LAMA 1; LAMA; LAMA1; LAMB1; Laminin A chain; Laminin alpha 1; Laminin alpha 1 chain; Laminin B1 chain; Laminin subunit beta 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学 信号转导 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 198kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human laminin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies.
Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Location:
Secreted > extracellular space > extracellular matrix > basement membrane.
Tissue Specificity:
Broadly expressed in: skin, heart, lung, and the reproductive tracts.
Similarity:
Contains 11 laminin EGF-like domains.
Contains 1 laminin IV type A domain.
Contains 1 laminin N-terminal domain.
Database links:Entrez Gene: 10319 Human
EntrezGene: 284217 Human
Entrez Gene: 3908 Human
Entrez Gene: 3912 Human
Entrez Gene: 3913 Human
Entrez Gene: 3915 Human
Entrez Gene: 3918 Human
Entrez Gene: 16772 Mouse
Entrez Gene: 316758 Rat
Omim: 150320 Human
SwissProt: P07942 Human
SwissProt: P24043 Human
SwissProt: P25391 Human
SwissProt: P55268 Human
SwissProt: Q9Y6N6 Human
SwissProt: P19137 Mouse
SwissProt: Q9R0B6 Mouse
Unigene: 201805 Human
Unigene: 270364 Human
Unigene: 302362 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
层粘连蛋白主要存在于基膜(basal lamina)结构中，是基膜所特有的非胶原糖蛋白。
层粘连蛋白在细胞发育过程中刺激细胞粘着、细胞运动。LN能够刺激胚胎中神经轴的生长,并促进成年动物的神经损伤后重生长和再生。如同纤粘连蛋白,细胞外的LN能够影响细胞的生长、迁移和分化。LN在原生殖细胞的迁移中起关键作用。
层粘连蛋白是细胞外基底膜的主要组成部分，分布于基底膜和细胞外基质内、成纤维细胞、内皮细胞和平滑肌细胞分泌层粘连蛋白。肿瘤的浸润和转移与其遭到破坏相关。该抗体可用于标记基底膜，有助于观察肿瘤周围基底膜的分布及其改变，间接提示该肿瘤的分化程度和浸润情况。