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货号： bs-0531R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0531R-PE-Cy7
- 英文名称
- Anti-Matriptase/PE-Cy7
- 中文名称
- PE-Cy7标记的蛋白裂解酶（一种新的癌基因）抗体
- 别 名
- transmembrane protease, serine 6; 1300008A22Rik; IRIDA; MATRIPTASE2; TMPRSS6.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 激酶和磷酸酶 合成与降解
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 94kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Matriptase (16-40aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
Subunit:
Interacts with CDCP1. May interact with TMEFF1.
Subcellular Location:
Membrane; Single-pass type II membrane protein (Probable).
Similarity:
Belongs to the peptidase S1 family.
Contains 2 CUB domains.
Contains 4 LDL-receptor class A domains.
Contains 1 peptidase S1 domain.
Database links:Entrez Gene: 164656 Human
Entrez Gene: 71753 Mouse
Entrez Gene: 315388 Rat
Omim: 609862 Human
SwissProt: Q8IU80 Human
SwissProt: Q9DBI0 Mouse
Unigene: 370885 Human
Unigene: 34056 Mouse
Unigene: 214123 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白裂解酶是第一种已在分子水平上辨明的、与癌症相关的跨膜丝氨酸蛋白酶。他们的研究首次发现蛋白裂解酶可以诱发肿瘤。蛋白裂解酶是一种细胞膜蛋白，一直以来研究者们对这种蛋白裂解酶的致癌功能表示怀疑。
matriptase在多种上皮来源的肿瘤中均高水平表达，有学者认为：matriptase作为一种癌基因，为跨膜蛋白而且位于细胞表面，部分位于胞浆。