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货号： bs-0448R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0448R-PE-Cy7
- 英文名称
- Anti-NIS/PE-Cy7
- 中文名称
- PE-Cy7标记的钠碘转运体蛋白抗体
- 别 名
- Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na+/I- cotransporter; Na+/I-symporter; NIS; SC5A5_HUMAN; SLC5A5; sodium iodide symporter; Sodium-iodide symporter; Sodium/iodide cotransporter; Solute carrier family 5 (sodium iodide symporter) member 5; Solute carrier family 5; Solute carrier family 5 member 5.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学 通道蛋白 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NIS C-terminus
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
catalyzes Na+/I- symporter activity plays a role in iodide transport and thyroid hormone generation.
Human Sodium Iodide Symporter (hNIS) is responsible for iodide concentrating ability within thyroid follicular cells. It is a membrane bound glycoprotein with 13 membrane spanning domains and 14 extramembranous domains. It may represent an autoantigen in thyroid.
Function:
Mediates iodide uptake in the thyroid gland.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.
DISEASE:
Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Database links:Entrez Gene: 6528 Human
Entrez Gene: 114613 Rat
Omim: 601843 Human
SwissProt: Q92911 Human
SwissProt: Q63008 Rat
Unigene: 103983 Human
Unigene: 584804 Human
Unigene: 10505 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钠/碘转运体蛋白-NIS，是位于甲状腺细胞基底膜上的一类膜抗原，在甲状腺对碘的主动转运过程中发挥重要作用。
钠/碘转运蛋白受甲状腺刺激素(TSH)、碘、细胞因子和生长因子等多种因素的广泛调节。自身免疫性甲状腺疾病时NIS的表达发生了明显变化，患者体内出现抗NIS自身抗体。
此外，NIS还与甲状腺冷结节和先天性甲状腺机能减退等甲状腺疾病的发病机理密切相关，近年来得到了足够的重视。