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货号： bs-1073R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1073R-PE-Cy7
- 英文名称
- Anti-Nm23-H2/NME2/PE-Cy7
- 中文名称
- PE-Cy7标记的肿瘤抑制基因NME2抗体
- 别 名
- nucleoside dIPhosphatase kinase B; C myc purine binding transcription factor PUF; NDK B; NDKB; NDP kinase B; NDPKB; NM23 H2; NM23B; Nucleoside diphosphate kinase B; nm23-M2; NME2; Nucleoside diphosphate kinase alpha, p18-12d; puf; MGC107562; MGC107563; MGC111212; non-metastatic cells 2, protein (NM23B)expressed in; NDKB_HUMAN; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; nm23-H2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 17kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Nm23
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
NM23 is a heterodimeric protein functioning as a nucleoside diphosphate (NDP) kinase. NME1 and NME2 comprise the 152 amino acid A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases are involved in the synthesis of nucleoside triphosphates, and NM23 may act in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways. NEM2 has been identified as a putative tumor suppressor. High expression of mouse NME2 is detected in heart, liver, and kidney, with moderate expression in skeletal muscle, and negligible expression in other mouse tissues examined.
Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Subunit:
Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8. Interacts with AKAP13.
Subcellular Location:
Cytoplasm. Nucleus. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the NDK family.
Database links:Entrez Gene: 395916 Chicken
Entrez Gene: 480559 Dog
Entrez Gene: 4831 Human
Entrez Gene: 654364 Human
Entrez Gene: 18103 Mouse
Entrez Gene: 83782 Rat
Omim: 156491 Human
SwissProt: Q3T0Q4 Cow
SwissProt: Q50KA8 Dog
SwissProt: P22392 Human
SwissProt: Q01768 Mouse
SwissProt: Q2EN76 Pig
SwissProt: P19804 Rat
Unigene: 463456 Human
Unigene: 1260 Mouse
Unigene: 927 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Nm23-H2在高转移性的肿瘤中呈现低表达，提示NM23-H2具有转移抑制的功能。其抑制肿瘤转移机制为增强微丝、微管的聚合，影响细胞的移动，从而抑制肿瘤的侵袭和转移。