产品中心
当前位置：首页>产品中心Anti-Neurotrophin 4/PE-Cy7
货号： bs-0158R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0158R-PE-Cy7
- 英文名称
- Anti-Neurotrophin 4/PE-Cy7
- 中文名称
- PE-Cy7标记的神经生长因子4/5抗体
- 别 名
- GLC1O; Neurotrophic factor 4; Neurotrophic factor 5; Neurotrophin 4/5; Neurotrophin 5 (neurotrophin 4/5); Neurotrophin 5; Neurotrophin-4; Neurotrophin-5; Neurotrophin4; Neurotrophin4/5; Neurotrophin5; Neutrophic factor 4; Neutrophic factor 5; NT 4; NT-4; NT 4/5; NT-4/5; NT 5; NT-5; NT4; NT4/5; NT4P; NT5; NTF 4; NTF 5; NTF4; NTF4_HUMAN; NTF5
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 14/27kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NT-4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Neurotrophin 4 (NT4; synonymous with NT5) belongs to the NGF beta family and is a survival factor for peripheral sensory sympathetic neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. NT4 levels are highest in the prostate, with lower levels in thymus, placenta, and skeletal muscle. NT4 is also expressed in embryonic and adult tissues.
Function:
Target-derived survival factor for peripheral sensory sympathetic neurons.
Subcellular Location:
Secreted.
Tissue Specificity:
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
DISEASE:
Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Similarity:
Belongs to the NGF-beta family.
Database links:Entrez Gene: 4909Human
Entrez Gene: 78405Mouse
Entrez Gene: 25730Rat
Omim: 162662Human
SwissProt: P34130Human
SwissProt: Q80VU4Mouse
SwissProt: P34131Rat
Unigene: 266902Human
Unigene: 20344Mouse
Unigene: 44225Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Neurotrophic factor 4/5起源于同一基因家族， 故可称为NGF家族。神经生长因子4/5具有促进早期神经元的增殖与分化，维持成熟神经元的存活的生物学功能,能调控神经元再生的微环境、可促进运动神经元的存活和生长并能防止它受损及死亡。