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货号： bs-1110R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1110R-PE-Cy7
- 英文名称
- Anti-Osterix/PE-Cy7
- 中文名称
- PE-Cy7标记的成骨相关转录因子抗体
- 别 名
- Osterix; MGC126598; Osx; Sp 7; Sp7; Sp7 transcription factor; Transcription factor Sp7; Zinc finger protein osterix; SP7_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 染色质和核信号 信号转导 干细胞 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 45kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Osterix
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]
Function:
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
Subunit:
Interacts with NO66; the interaction is direct and inhibits transcription activator activity.
Subcellular Location:
Nucleus.
Tissue Specificity:
Osteoblast/chondrocyte specific.
DISEASE:
Osteogenesis imperfecta 12 (OI12) [MIM:613849]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
Database links:Entrez Gene: 121340 Human
Entrez Gene: 170574 Mouse
Entrez Gene: 300260 Rat
Omim: 606633 Human
SwissProt: Q8TDD2 Human
SwissProt: Q5RM08 Mouse
SwissProt: Q8VI67 Mouse
SwissProt: Q6IMK1 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Osterix成骨相关转录因子是一种具有锌指基序结构域的转录因子，在体内的表达对成骨细胞具有特异性。该蛋白只在发育的骨组织中特异性表达，是成骨细胞分化和骨形成过程中所必需的转录因子。骨髓基质干细胞分化为表达典型的成骨性标志基因的成骨细胞需要OSX的调控。