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货号： bs-1095R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1095R-PE-Cy7
- 英文名称
- Anti-Orexin receptor 1+2/PE-Cy7
- 中文名称
- PE-Cy7标记的丘脑分泌素受体1+2/食欲素受体1+2抗体
- 别 名
- Orexin Receptor 1 and 2; Orexin receptor 1 + 2; Orexin Receptor 2; HCRTR 1; HCRTR1; Hypocretin receptor type 1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1r; OX1R_HUMAN; Hcrtr2; Hypocretin (orexin) receptor 2; Hypocretin receptor 2; Hypocretin receptor type 2; Orexin receptor 2; Orexin receptor type 2; Ox-2-R; Ox2-R; Ox2r; OX2R_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 信号转导 通道蛋白 细胞膜受体 内分泌病 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Orexin receptor 1/2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
Function:
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 3061Human
Entrez Gene: 230777Mouse
Entrez Gene: 25593Rat
Omim: 602392Human
SwissProt: O43613Human
SwissProt: P58307Mouse
SwissProt: P56718Rat
Unigene: 388226Human
Unigene: 246595Mouse
Unigene: 88262Rat
Entrez Gene: 3062Human
Entrez Gene: 387285Mouse
Entrez Gene: 25605Rat
Omim: 602393Human
SwissProt: O43614Human
SwissProt: P58308Mouse
SwissProt: P56719Rat
Unigene: 151624Human
Unigene: 699147Human
Unigene: 335300Mouse
Unigene: 9893Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
食欲素受体(OXR)Orexin receptor—是一种G蛋白偶合受体. 下丘脑是调节饮食及能量平衡的中枢.学者认为：在下丘脑可促进食欲且来源于同一前体的两种新神经肽:食欲素A和B,它们可激活两种密切相关且与G蛋白偶联的细胞表面受体(OX1R,OX2R).含Orexin的神经细胞在下丘脑腹外侧呈对称的不连贯分布. 在饮食反馈调节中具有重要作用.食欲素与其它影响进食的神经肽之间存在错综复杂的关系.它在增加摄食、饮水、调节睡眠觉醒周期、生殖、体温、血压和感觉等方面有广泛作用.