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货号： bs-0828R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0828R-PE-Cy7
- 英文名称
- Anti-Thrombin receptor/ PAR1/PE-Cy7
- 中文名称
- PE-Cy7标记的蛋白酶激活受体-1抗体
- 别 名
- SAR; BXR; Proteinase-activated receptor 1 precursor; Thrombin receptor; Coagulation factor II receptor; D15S227E; Prader-Willi/Angelman region-1; PAR1; Coagulation factor II receptor; CF2R; Coagulation factor II (thrombin) receptor; F2R; HTR; PAR 1; PAR1; Protease activated receptor 1; Proteinase activated receptor 1; Thrombin receptor; TR; PAR-1; Coagulation factor II receptor; Coagulation factor II receptor; PAR-1; PAR1_HUMAN; Proteinase activated receptor 1; Proteinase-activated receptor 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 激酶和磷酸酶 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 42kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PAR1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]
Function:
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Platelets and vascular endothelial cells.
Post-translational modifications:
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 2149Human
Omim: 187930Human
SwissProt: P56488Baboon
SwissProt: P25116Human
Unigene: 482562Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PAR蛋白全称为蛋白酶体活化受体(Protease-activated receptors)，又称：凝血酶受体(Thrombin Receptor)是独立家族的G蛋白偶联受体， 研究认为与炎症，实体肿瘤等密切相关。
PAR1蛋白是乳腺癌细胞侵润和迁移的必需因子，它是作为基质金属蛋白酶体1（MMP-1）的受体关键性作用，这一研究结果为研制新的抗癌药物提供新的靶点。