产品中心
当前位置：首页>产品中心Anti-PLGF/PE-Cy7
货号： bs-0280R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0280R-PE-Cy7
- 英文名称
- Anti-PLGF/PE-Cy7
- 中文名称
- PE-Cy7标记的胎盘生长因子抗体
- 别 名
- Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学 生长因子和激素 转录调节因子 细胞表面分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat, Pig,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 16kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse PLGF
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Function:
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
Subunit:
Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF.
Subcellular Location:
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Tissue Specificity:
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the PDGF/VEGF growth factor family.
Database links:Entrez Gene: 5228Human
Entrez Gene: 18654Mouse
Entrez Gene: 94203Rat
Omim: 601121Human
SwissProt: P49763Human
SwissProt: P49764Mouse
SwissProt: Q63434Rat
Unigene: 252820Human
Unigene: 4809Mouse
Unigene: 6960Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PLGF胎盘生长因子是血管生长因子家族成员之一（又称：胎盘型血管内皮细胞生长因子），是动脉粥样硬化斑块不稳定的主要炎性激活物，因此它可作为ACS患者风险预测的生物学标志物.尿胎盘生长因子水平可预测先兆子痫危险.研究人员发现，在疾病发作前的6到8周，先兆子痫患者尿液中的胎盘生长因子水平急剧下降,这种新的尿检方法使提前1到2个月预测先兆子痫成为可能。亦有研究人员正在从事胎盘生长因子与肺气肿，胃癌，肠癌等方面的研究。