Anti-SOCS1/PE-Cy7【科瑞奥博】

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Anti-SOCS1/PE-Cy7

货号： bs-0113R-PE-Cy7 基本售价： 2980.0 元规格： 100ul

产品信息

产品编号: bs-0113R-PE-Cy7

英文名称: Anti-SOCS1/PE-Cy7

中文名称: PE-Cy7标记的细胞因子信号传导抑制蛋白1抗体

别名: CISH 1; CISH1; Cytokine Inducible SH2 Protein 1; JAB; JAK Binding Protein; Janus kinase binding protein; SOCS 1; SOCS1; SOCS-1; SSI 1; SSI1; STAT Induced STAT Inhibitor 1; Supressor of cytokine Signalling 1; TEC Interacting Protein 3; TIP 3; TIP3; SOCS1_HUMAN.

规格价格: 100ul/2980元购买大包装/询价

说明书: 100ul

研究领域: 细胞生物神经生物学信号转导细胞凋亡转录调节因子

抗体来源: Rabbit

克隆类型: Polyclonal

交叉反应: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,

产品应用: IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量: 23kDa

性状: Lyophilized or Liquid

浓度: 1mg/ml

免疫原: KLH conjugated synthetic peptide derived from human Socs 1

亚型: IgG

纯化方法: affinity purified by Protein A

储存液: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍

background:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor(LIF). Regulates interferon-gamma mediated sensory neuron survival. Implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. High expression in thymus. Lower expression in lung and spleen.

Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Subunit:
Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with AXL, CUL2 and FGFR3. Interacts with INSR.

Subcellular Location:
Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Tissue Specificity:
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

Similarity:
Contains 1 SH2 domain. Contains 1 SOCS box domain.

Database links:

Entrez Gene: 8651 Human

Entrez Gene: 12703 Mouse

Entrez Gene: 252971 Rat

Omim: 603597 Human

SwissProt: O15524 Human

SwissProt: O35716 Mouse

SwissProt: Q9QX78 Rat

Unigene: 50640 Human

Unigene: 130 Mouse

Unigene: 82754 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞因子信号传导抑制蛋白(suppressor of cytokine signaling, SOCS)家族是一类由细胞产生并反馈性阻断细胞因子信号转导过程的负性调节因子，SOCS1可抑制IL-6、LIF、OSM、INF-γ以及GH等多种细胞因子的信号转导，对体内多种免疫反应的激活起调控作用。SOCS1异常表达与多种疾病的发病相关，在急慢性白血病、类风湿性关节炎、肝硬化和肝癌的发病中起重要作用；对信号转导，特别是JAKSTAT通路的负调控作用已被肯定。