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货号： bs-0416R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0416R-PE-Cy7
- 英文名称
- Anti-TIMP-2/PE-Cy7
- 中文名称
- PE-Cy7标记的金属蛋白酶组织抑制因子-2抗体
- 别 名
- Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 神经生物学 信号转导 细胞凋亡 生长因子和激素 合成与降解
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TIMP-2 (125-160aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008].
Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Subunit:
Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
Subcellular Location:
Secreted.
Post-translational modifications:
The activity of TIMP2 is dependent on the presence of disulfide bonds.
Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.
Database links:Entrez Gene: 282093 Cow
Entrez Gene: 100135629 Guinea pig
Entrez Gene: 7077 Human
Entrez Gene: 21858 Mouse
Entrez Gene: 100008689 Rabbit
Entrez Gene: 29543 Rat
Omim: 188825 Human
SwissProt: P16368 Cow
SwissProt: Q9WUC6 Guinea pig
SwissProt: P16035 Human
SwissProt: P25785 Mouse
SwissProt: Q9TRZ7 Rabbit
SwissProt: P30121 Rat
Unigene: 633514 Human
Unigene: 206505 Mouse
Unigene: 10161 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
合成与降解（Synthesis and Degradation）
TIMP-2与TIMP-1一样是基质金属蛋白酶的抑制酶，其功能与MMP相反，能抑制肿瘤细胞的浸润和转移，主要用于各种恶性肿瘤如乳腺癌等的研究。TIMP-2又称为CSC-21K，是一种21-24kDa的糖蛋白，在多种组织细胞中表达，它可以和MMPs家族成员以共价键方式形成复合物，从而发挥其抑制作用。在正常生理条件下，MMPs和TIMPs之间的平衡状态是维持细胞外基质正常状态所必需的，一旦它们之间的比例失调，就会造成一系列的病理状态。