产品中心
当前位置：首页>产品中心Anti-TIMP-3/PE-Cy7
货号： bs-0417R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0417R-PE-Cy7
- 英文名称
- Anti-TIMP-3/PE-Cy7
- 中文名称
- PE-Cy7标记的金属蛋白酶组织抑制因子-3抗体
- 别 名
- HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; TIMP3; TIMP 3; MIG 5 protein; MIG5 protein; Protein MIG 5; SFD; Sorsby fundus dystrophy pseudoinflammatory; TIMP metallopeptidase inhibitor 3; TIMP3; Tissue Inhibitor of Metalloproteinase 3; Tissue inhibitor of metalloproteinases3; TIMP3_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 神经生物学 信号转导 细胞凋亡 合成与降解
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 21kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TIMP-3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsbys fundus dystrophy. [provided by RefSeq, Jul 2008].
Subunit:
Interacts with EFEMP1.
Subcellular Location:
Secreted, extracellular space, extracellular matrix.
Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.
Database links:Entrez Gene: 7078 Human
Entrez Gene: 21859 Mouse
Entrez Gene: 25358 Rat
Omim: 188826 Human
SwissProt: P35625 Human
SwissProt: P39876 Mouse
SwissProt: P48032 Rat
Unigene: 644633 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
合成与降解（Synthesis and Degradation）
近年来，国内外科研人员对TIMP-3的抗肿瘤作用日益被重视，学者认为：TIMP-3具有强烈促凋亡、抑制血管生成、抗肿瘤浸润作用，TIMP-3与TIMP-1、2且相互间有明显协同抗肿瘤作用