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货号： bs-0716R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0716R-PE-Cy7
- 英文名称
- Anti-CIDEB/PE-Cy7
- 中文名称
- PE-Cy7标记的CIDEB抗体
- 别 名
- cell death activator CIDE-B; Cell death activator CIDE B; Cell death inducing DFFA like effector B; CIDEB_HUMAN; cell death-inducing DFFA-like effector B; Cide-b.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 染色质和核信号 细胞凋亡 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CIDEB (115-160aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as an inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE B induces apoptosis, which is inhibited by DFF45. CIDE B is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE B is expressed mainly in liver and small intestine and at lower levels in spleen, colon, kidney, peripheral blood lymphocytes, and bone marrow.
Function:
Activates apoptosis.
Subunit:
Inhibited by DFFB. Interacts with DFFA and DFFB.
Tissue Specificity:
Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.
Similarity:
Contains 1 CIDE-N domain.
Database links:Entrez Gene: 27141 Human
Entrez Gene: 12684 Mouse
Entrez Gene: 364388 Rat
Omim: 604441 Human
SwissProt: Q546V8 Human
SwissProt: Q9UHD4 Human
SwissProt: O70303 Mouse
Unigene: 642693 Human
Unigene: 696081 Human
Unigene: 708040 Human
Unigene: 466766 Mouse
Unigene: 204016 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CIDEB是在细胞凋亡的过程中诱导分泌的一种蛋白，在棕色脂肪组织，肝脏和肾脏中发现有高水平的DFF45-like effector--DFF45样效应子b蛋白，简称cideb。CIDEB具有调控脂质代谢的作用。