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货号： bs-0449R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0449R-PE-Cy7
- 英文名称
- Anti-TSLP/PE-Cy7
- 中文名称
- PE-Cy7标记的胸腺基质淋巴细胞生成素-1抗体
- 别 名
- Thymic stromal lymphopoietin isoform 1; Thymic stromal lymphopoietin; Thymic stromal lymphopoietin protein TSLP; TSLP protein; TSLP_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 细胞因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 15kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TSP-1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Thymic stromal lymphopoietin (TSLP) is a novel cytokine that was found to promote the development of murine B cells in vitro. This protein, which is expressed in a number of tissues including heart, liver and prostate, prevented apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ-3. Anti-interleukin (IL)-7 receptor antibodies (Abs) neutralized this effect indicating that TSLP binds to at least part of the IL-7 receptor complex. TSLP induced phosphorylation of signal transducer and activator of transcription (STAT)-5.
Function:
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Subunit:
Interacts with a receptor composed of CRLF2 and IL7R.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in a number of tissues including heart, liver and prostate.
Database links:Entrez Gene: 85480 Human
Entrez Gene: 53603 Mouse
Entrez Gene: 688621 Rat
Omim: 607003 Human
SwissProt: Q969D9 Human
SwissProt: Q9JIE6 Mouse
Unigene: 389874 Human
Unigene: 143716 Mouse
Unigene: 201724 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胸腺基质淋巴细胞生成素-1（胸腺基质细胞分泌的淋巴细胞生成素-1）
为一种新型促进生长的细胞因子——胸腺基质淋巴蛋白（TSLP）可以引发炎症反应，这种炎症反应可以引起很多过敏性疾病和哮喘。
TSLP可能是过敏性疾病最重要的引发剂，已得到科学家的重视，如果证实了TSLP是一种起始因子，抑制TSLP可以有效地治疗哮喘和其它过敏性疾病。