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货号： bs-1331R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1331R-PE-Cy7
- 英文名称
- Anti-SFRP4/PE-Cy7
- 中文名称
- PE-Cy7标记的子宫内膜抗体
- 别 名
- sFRP-4; Secreted frizzled-related protein 4; Frizzled protein, human endometrium; FrpHE; SFRP4; SFRP4_MOUSE; SFRP4_HUMAN; FRPHE.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学 干细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human sFRP-4 C-terminus
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. [SUBCELLULAR LOCATION] Secreted. Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Belongs to the secreted frizzled-related protein (sFRP) family.
Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung.
Similarity:
Belongs to the secreted frizzled-related protein (sFRP) family.
Contains 1 FZ (frizzled) domain.
Contains 1 NTR domain.
Database links:Entrez Gene: 6424 Human
Entrez Gene: 20379 Mouse
Entrez Gene: 89803 Rat
Omim: 606570 Human
SwissProt: Q6FHJ7 Human
SwissProt: Q9Z1N6 Mouse
SwissProt: Q9JLS4 Rat
Unigene: 658169 Human
Unigene: 42095 Mouse
Unigene: 10788 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
抗子宫内膜抗体属于自身抗体，在正常育龄妇女中也可以检测到，但在不孕症人群中，特别是患有子宫内膜异位症的妇女中更多见。
正常机体具有自身免疫调节功能，产生极弱的自身抗体，帮助清除体内衰老变性的自身成分，但由于某种原因导致免疫系统对自身组织产生过度免疫应答，则会发生过强的一系列免疫反应，致使所侵及的组织免疫活性细胞增多，免疫复合物沉积，而导致功能改变。当这种抗子宫内膜抗体由于反复刺激而大量产生达到一定的含量时，可与自身的子宫内膜组织发生抗原抗体结合反应，并激活免疫系统引起损伤性效应，造成子宫内膜组织细胞生化代谢及生理功能的损害，干扰和妨碍精卵结合，受精卵的着床和胚囊的发育而导致不孕或流产。