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货号： bs-1896R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1896R-PE-Cy7
- 英文名称
- Anti-SOCS2/PE-Cy7
- 中文名称
- PE-Cy7标记的细胞因子信号传导抑制蛋白2抗体
- 别 名
- suppressor of cytokine signaling 2; suppressor of cytokine signaling SOCS2; CIS2; SOCS 2; Cish2; SSI-2; STATI2; SOCS2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 信号转导 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 23kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Socs 2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subunit:
Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.
Tissue Specificity:
High expression in heart, placenta, lung, kidney and prostate.
Similarity:
Contains 1 SH2 domain.
Contains 1 SOCS box domain.
Database links:Entrez Gene: 8835 Human
Entrez Gene: 216233 Mouse
Entrez Gene: 84607 Rat
Omim: 605117 Human
SwissProt: O14508 Human
SwissProt: O35717 Mouse
SwissProt: O88582 Rat
Unigene: 485572 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞因子信号传导抑制蛋白(suppressor of cytokine signaling, SOCS)家族是一类由细胞产生并反馈性阻断细胞因子信号转导过程的负性调节因子，SOCS2可抑制IL-6、LIF、OSM、INF-γ以及GH等多种细胞因子的信号转导，对体内多种免疫反应的激活起调控作用。SOCS2异常表达与多种疾病的发病相关，在急慢性白血病、类风湿性关节炎、肝硬化和肝癌的发病中起重要作用；对信号转导，特别是JAKSTAT通路的负调控作用已被肯定。