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货号： bs-0850R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0850R-PE-Cy7
- 英文名称
- Anti-S100A1/PE-Cy7
- 中文名称
- PE-Cy7标记的S100A1抗体
- 别 名
- S100; S-100 protein alpha subunit; S-100 protein alpha chain; Protein S100-A1; S100 calcium-binding protein A1; S100 alpha; Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 Calcium Binding Protein A1; S100 calcium-binding protein A1; S100 protein alpha polypeptide; S100A; S10A1_HUMAN; S-100 α; S-100-α; S-100α.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 10kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human S100A1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Function:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
Subunit:
Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.
Similarity:
Belongs to the S-100 family.
Contains 2 EF-hand domains.
Database links:Entrez Gene: 6271Human
Entrez Gene: 20193Mouse
Entrez Gene: 295214Rat
Omim: 176940Human
SwissProt: P23297Human
SwissProt: P56565Mouse
SwissProt: P35467Rat
Unigene: 515715Human
Unigene: 24662Mouse
Unigene: 11091Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
星型胶质细胞标志物
S100A1是钙结合蛋白家族S100亚家族中一个小分子量的酸性蛋白，对稳定蛋白质分子的构象起到一定的作用。