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货号： bs-1334R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1334R-PE-Cy7
- 英文名称
- Anti-TIE1/PE-Cy7
- 中文名称
- PE-Cy7标记的血管生成素受体1抗体
- 别 名
- TIE1_HUMAN; JKT 14; JTK14; TIE; Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains; Tyrosine protein kinase receptor Tie 1; Tyrosine-protein kinase receptor Tie-1; tyrosine kinase receptor 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 信号转导 干细胞 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 123kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Tie1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Due to glycosylation, the protein migrates to approximately 160 kDa in SDS PAGE under reducing conditions. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation. The receptor tyrosine kinase TIE also plays a role in the survival and integrity of the endothelium.
Function:
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Subunit:
Heterodimer with TEK/TIE2.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Specifically expressed in developing vascular endothelial cells.
Post-translational modifications:
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Contains 3 EGF-like domains.
Contains 3 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
Database links:Entrez Gene: 280941 Cow
Entrez Gene: 7075 Human
Entrez Gene: 21846 Mouse
Entrez Gene: 89806 Rat
Omim: 600222 Human
SwissProt: Q06805 Cow
SwissProt: P35590 Human
SwissProt: Q06806 Mouse
Unigene: 78824 Human
Unigene: 4345 Mouse
Unigene: 13171 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血管生成素-1受体又称上皮生长因子样域酪氨酸激酶1或内皮酪氨酸激酶受体,Tie1在血管内皮细胞、腺上皮及间质细胞中均有表达，主要定位于细胞质。