产品中心
当前位置：首页>产品中心Anti-APG4B/PE-Cy7
货号： bs-1384R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1384R-PE-Cy7
- 英文名称
- Anti-APG4B/PE-Cy7
- 中文名称
- PE-Cy7标记的自噬相关蛋白4B抗体
- 别 名
- APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); AUT like 1 cysteine endopeptidase; AUTL1; Autophagin 1; Autophagy related cysteine endopeptidase 1; Autophagy related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; MGC1353br.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 44kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human APG4B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function:
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Subcellular Location:
Cytoplasm (Probable).
Tissue Specificity:
Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.
Similarity:
Belongs to the peptidase C54 family.
Database links:Entrez Gene: 23192Human
Entrez Gene: 66615Mouse
Entrez Gene: 316640Rat
Omim: 611338Human
SwissProt: Q9Y4P1Human
SwissProt: Q8BGE6Mouse
SwissProt: Q62625Rat
Unigene: 283610Human
Unigene: 29087Mouse
Unigene: 163086Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞自噬（Autophagy）是一种非凋亡性的程序性细胞死亡即自噬性程序性细胞死亡，进化过程中高度保守，清除降解细胞内受损伤的细胞结构、衰老的细胞器、以及不再需要的生物大分子等，在细胞的生长、发育和疾病发生中起着重要的作用。细胞自噬是一个高效调控过程，特异性激酶和鸟嘌呤核苷酸磷酸酶（GTPases）在调节自噬通道活性中起着关键作用.