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货号： bs-0930R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0930R-PE-Cy7
- 英文名称
- Anti-phospho-heterochromatin protein 1 (pTyr41)/PE-Cy7
- 中文名称
- PE-Cy7标记的异染色质蛋白1磷酸化抗体（果蝇）
- 别 名
- Antigen p25; Cbx 5; Cbx5 antibody Chromobox homolog 5 (Drosophila HP1 alpha); Chromobox homolog 5 (HP1 alpha homolog Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Chromobox protein homologue 5 ; Heterochromatin protein 1 alpha; Heterochromatin protein 1; Heterochromatin protein 1 homolog alpha; HP 1; HP 1A; HP1 alpha homolog ; HP1A ; HP1Hs alpha; HP1Hs-alpha.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 细胞生物 免疫学 染色质和核信号 昆虫
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Fruit Fly,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 23kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated Synthesised phosphopeptide derived from Fruit Fly HP1 around the phosphorylation site of Tyr41
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.
Database links:
GenBank: ACI96782.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
异染色质蛋白1（Heterochromatin protein 1 (HP1)）一般认为是异染色质的维持者，异染色质是转录沉默的固缩DNA，常常与中心粒等区域有关。这种固缩的DNA被认为是转录因子无法接近的，但近期的Science上发表的两篇报道对这个观点提出了挑战。这个新的研究提出HP1可能是异染色质活性调控的重要因子，在细胞生理活动中具有的重要功能。