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货号： bs-1449R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1449R-PE-Cy7
- 英文名称
- Anti-Prohibitin/PE-Cy7
- 中文名称
- PE-Cy7标记的抑制素/肿瘤抑制因子抗体
- 别 名
- Mitochondrial Marker; PHB; prohibitin; PHB1; Prohibitin - Mitochondrial Marker; PHB_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 染色质和核信号 细胞凋亡 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 30kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Prohibitin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3 UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Function:
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
Subunit:
Interacts with PHB2. Interacts with STOML2.
Subcellular Location:
Mitochondrion inner membrane.
Tissue Specificity:
Widely expressed in different tissues.
Similarity:
Belongs to the prohibitin family.
Database links:Entrez Gene: 5245 Human
Entrez Gene: 18673 Mouse
Entrez Gene: 25344 Rat
Omim: 176705 Human
SwissProt: P35232 Human
SwissProt: P67778 Mouse
SwissProt: P67779 Rat
Unigene: 514303 Human
Unigene: 263862 Mouse
Unigene: 29754 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Prohibitin(phb)基因是一种有效的肿瘤抑制基因，广泛分布于不同种属的各种生物细胞中，它所编码的产物Prohibitin(PHB)蛋白结构保守，既存在于线粒体内膜上，发挥分子伴侣作用，也存在于细胞核内，具有负性转录调控作用，因而对细胞代谢、生长、分化、衰老以及凋亡等诸多方面发挥 着重要的调控作用，可能与某些肿瘤和退行性疾病的发生有关。