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货号： bs-1483R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1483R-PE-Cy7
- 英文名称
- Anti-RBBP6/PE-Cy7
- 中文名称
- PE-Cy7标记的增殖潜能相关蛋白抗体
- 别 名
- Retinoblastoma-binding protein 6; proliferation potential protein related; p53-associated cellular protein of testis; Proliferation potential-related protein; Retinoblastoma-binding Q protein 1; Protein RBQ-1; My038; PACT; Protein P2P-R; RBBP6_HUMAN; P2P-R.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 发育生物学 信号转导 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 201kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from humna P2PR
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
he retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
Subunit:
Interacts with p53/TP53 and RB1. Interacts also with MDM2 and YBX1. Interacts with NEK6.
Subcellular Location:
Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.
Tissue Specificity:
Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
Post-translational modifications:
Phosphorylated by NEK6.
Similarity:
Contains 1 CCHC-type zinc finger.
Contains 1 DWNN domain.
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 5930 Human
Entrez Gene: 19647 Mouse
Entrez Gene: 308968 Rat
Omim: 600938 Human
SwissProt: Q7Z6E9 Human
SwissProt: P97868 Mouse
Unigene: 188553 Human
Unigene: 4480 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号传导（Signaling Intermediates）
P2P-P又称PACT即P53相关细胞蛋白（P53 associated cellular protein-testes derived）， P2P-P蛋白是p53的负调控因子，而且在细胞生长和胚胎发育，细胞分化、前体mRNA剪接、周期阻滞、凋亡过程中起到了重要作用。