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货号： bs-1484R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1484R-PE-Cy7
- 英文名称
- Anti-MTHFR/PE-Cy7
- 中文名称
- PE-Cy7标记的亚甲基四氢叶酸还原酶MTHFR抗体
- 别 名
- 5 10 methylenetetrahydrofolate reductase (NADPH); 5 10 methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase intermediate form; MTHR_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 75kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MTHFR
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to neural tube defects, occlusive vascular disease, colon cancer and acute leukemia. Mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.
Function:
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
Subunit:
Homodimer.
DISEASE:
Methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]: Autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders. Note=The disease is caused by mutations affecting the gene represented in this entry.
Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Folate-sensitive neural tube defects (FS-NTD) [MIM:601634]: The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Similarity:
Belongs to the methylenetetrahydrofolate reductase family.
Database links:Entrez Gene: 4524 Human
Entrez Gene: 17769 Mouse
Entrez Gene: 362657 Rat
Omim: 607093 Human
SwissProt: P42898 Human
SwissProt: Q9WU20 Mouse
Unigene: 214142 Human
Unigene: 89959 Mouse
Unigene: 10494 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)是叶酸代谢的关键酶,为细胞内的各种甲基化反应提供甲基基团,在DNA甲基化中起重要作用。