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货号： bs-1475R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1475R-PE-Cy7
- 英文名称
- Anti-Gremlin/PE-Cy7
- 中文名称
- PE-Cy7标记的骨形态形成蛋白拮抗蛋白抗体
- 别 名
- CKTSF1B1; GREMLIN-1; GREMLIN 1; GREMLIN1; Cysteine knot superfamily BMP antagonist 1; DAND2; DRM; GREMLIN; Gremlin1; Gremlin 1; Gremlin-1; IHG2; PIG2; proliferation inducing gene 2 protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul q15. Gremlin 1-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of Gremlin 1 is associated with tumor progression, and support the hypothesis that human Gremlin 1 may play an important role during both neuroembryological development and carcinogenesis.
Function:
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.
Subunit:
Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner.
Subcellular Location:
Secreted.
Tissue Specificity:
Highly expressed in small intestine, fetal brain and colon. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts.
Similarity:
Belongs to the DAN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Database links:Entrez Gene: 26585 Human
Entrez Gene: 23892 Mouse
Entrez Gene: 50566 Rat
Omim: 603054 Human
SwissProt: O60565 Human
SwissProt: O70326 Mouse
SwissProt: O35793 Rat
Unigene: 40098 Human
Unigene: 166318 Mouse
Unigene: 42929 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
gremlin属于骨形态形成蛋白BMP拮抗剂家族成员,在胚胎发育过程中可通过调节BMP活性，影响器官、体征的形成和组织分化。