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货号： bs-1602R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1602R-PE-Cy7
- 英文名称
- Anti-SPA-1/PE-Cy7
- 中文名称
- PE-Cy7标记的信号感应增殖相关蛋白1抗体
- 别 名
- GTPase activating protein Spa 1; GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; p130 SPA1; Signal induced proliferation associated 1; Signal induced proliferation associated gene 1; Signal induced proliferation associated protein 1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; SIPA 1; Sipa-1; Sipa1; SIPA1_HUMAN; Spa1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 染色质和核信号 信号转导 干细胞 细胞凋亡 细胞周期蛋白 细胞表面分子 表观遗传学 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 112kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SPA-1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Function:
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
Subcellular Location:
Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.
Tissue Specificity:
Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
Similarity:
Contains 1 PDZ (DHR) domain.
Contains 1 Rap-GAP domain.
Database links:Entrez Gene: 6494 Human
Entrez Gene: 20469 Mouse
Omim: 602180 Human
SwissProt: Q96FS4 Human
SwissProt: P46062 Mouse
Unigene: 530477 Human
Unigene: 3072 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SPA 1是重要的Rap1GTP酶激活蛋白.SPA-1参与细胞的程序性死亡，在很多恶性肿瘤的发生、发展中起到一定的作用。