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货号： bs-1338R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1338R-PE-Cy7
- 英文名称
- Anti-Fx1A/PE-Cy7
- 中文名称
- PE-Cy7标记的肾刷状缘抗体
- 别 名
- gp330; RTEα5; LRP2_RAT; Low-density lipoprotein receptor-related protein 2; LRP-2; Glycoprotein 330; Megalin.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 518kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- Fx1A protein
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Binding of anti-Fx1A to Heymann nephritis antigens (HA) on rat glomerular epithelial cells (GECs) in culture leads to capping and disappearance of antigens from the cell surface. This process may contribute to the formation of glomerular subepithelial immune deposits in vivo. The authors differentially extracted GECs to determine whether HA redistribution is mediated by cytoskeletal components. Observations were made by phase-contrast and immunofluorescence microscopy on primary and passaged GECs in monolayer culture and by spectrofluorimetry on GECs in suspension.
Function:
Acts together with cubilin to mediate HDL endocytosis. Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.
Subunit:
Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP. Interacts (via NPXY motif) with DAB2; the interaction is not affected by tyrosine phosphorylation of the NPXY motif.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Cytoplasm. Note=Expressed in clathrin-coated pits, a soluble form is possibly derived by cleavage at the cell surface.
Tissue Specificity:
Epithelial cells of kidney glomerulus and proximal tubule, lung, epididymis, yolk sac, among others.
Similarity:
Belongs to the LDLR family.
Contains 17 EGF-like domains.
Contains 36 LDL-receptor class A domains.
Contains 37 LDL-receptor class B repeats.
Database links:Entrez Gene: 201456 Human
Entrez Gene: 361354 Rat
Omim: 609093 Human
SwissProt: Q8NCQ5 Human
Unigene: 664011 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
gp330是肾小管上皮细胞刷状缘上的一种大分子脂蛋白，Fx1A；经生物化学方法纯化后称RTEα5，Fx1A为大分子糖蛋白，近来证实它是—种330Ka的糖蛋白，现称gp330。
主要与肾小球上皮细胞整合素受体作用的抗刷状缘抗体(抗FX1A) 。