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货号： bs-1688R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1688R-PE-Cy7
- 英文名称
- Anti-HSP20/PE-Cy7
- 中文名称
- PE-Cy7标记的热休克蛋白-20抗体
- 别 名
- Heat Shock Protein 20; FLJ32389; Heat shock 20 kDa like protein p20; Heat shock protein alpha crystallin related B6; Heat shock protein beta 6; Hspb6; HSPB6_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 17kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HSP20
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Hsp20 is a small heat shock protein related to Hsp25, Hsp27 and may form different hetercomplexes with these proteins. The specific physiological function of Hsp20 is not yet known. It is distributed ubiquitously in tissues, but is found in higher levels in skeletal, smooth and heart muscle. Under normal conditions, Hsp20 is diffusely distributed in the cytosol, but under heat stress conditions, it translocates to the nucleus. Unlike other heat shock proteins the amount of Hsp20 does not increase after heat shock. The Hsp20 was demonstrated to constitute up to 1.3% of the total cellular protein in vertebrate tissues, especially in muscle, and its expression is related to muscle contraction, specifically in slow-twitch muscle. Hsp20 may form different heterocomplexes with other Hsps, such as alpha-crystalline and Hsp25. Phosphorylated form of Hsp20 is proposed to interact with monomeric actin whereas dephosphorylated form binds polymeric actin filaments. In normal conditions Hsp20 is diffusely disturbed in cytosol but under the heat stress it undergoes translocation to membrane fraction.
Subunit:
Homodimer (By similarity).
Subcellular Location:
Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.
Post-translational modifications:
The N-terminus is blocked.
Similarity:
Belongs to the small heat shock protein (HSP20) family.
Database links:Entrez Gene: 126393 Human
Entrez Gene: 243912 Mouse
Entrez Gene: 192245 Rat
SwissProt: O14558 Human
SwissProt: Q6NVI3 Human
SwissProt: Q5EBG6 Mouse
SwissProt: P97541 Rat
Unigene: 534538 Human
Unigene: 34885 Mouse
Unigene: 3201 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HSPs是细胞受应激原刺激后诱导产生的一组应激蛋白，与肿瘤发生、增殖及分化有关。按其分子量不同可分为多种类型，每组的HSPs的分布及功能有所不同。