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货号： bs-1934R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1934R-PE-Cy7
- 英文名称
- Anti-UCP-3/PE-Cy7
- 中文名称
- PE-Cy7标记的线粒体脱偶连蛋白3抗体
- 别 名
- Uncoupling Protein-3; UCP3; UCP 3; mitochondrial uncoupling protein 3; Solute carrier family 25 member 9; SLC25A9; UCP3_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 激酶和磷酸酶 线粒体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human UCP-3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The uncoupling proteins (UCPs) are found in the inner mitochondrial membranes and belong to a family of mitochondrial anion transport proteins that include the phosphate and oxologutarate carriers and the ADP/ATP translocator. Three UCP subtypes have been identified and cloned. UCP 1 is abundantly expressed in brown adipose tissue of mammals. UCP 1 allows proton re-entry into the mitochondrial matrix without involving the F0-F1 ATPase which produces heat instead of ATP. It is thought that UCP 2 and 3 also dissipate the mitochondrial proton gradient produced by the respiratory chain in cells and tissues within which they are expressed. Studies have shown UCP 2 to be expressed by a variety of tissues. UCP 3 is expressed predominantly in brown adipose tissue, skeletal muscle, at lower levels in heart and smooth muscle, and is absent in liver and kidney.
Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
Subcellular Location:
mitochondrial.Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue Specificity:
Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.
DISEASE:
Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=The gene represented in this entry may be involved in disease pathogenesis.
Similarity:
Belongs to the mitochondrial carrier family.
Database links:Entrez Gene: 7352 Human
Entrez Gene: 22229 Mouse
Entrez Gene: 397116 Pig
Entrez Gene: 25708 Rat
Omim: 602044 Human
SwissProt: P55916 Human
SwissProt: P56501 Mouse
SwissProt: O97649 Pig
SwissProt: P56499 Rat
Unigene: 101337 Human
Unigene: 621879 Human
Unigene: 6254 Mouse
Unigene: 9902 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.