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货号： bs-0644R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0644R-PE-Cy7
- 英文名称
- Anti-PTP4A2/PE-Cy7
- 中文名称
- PE-Cy7标记的肝再生磷酸酯酶2抗体
- 别 名
- Protein tyrosine phosphatase type IV A protein 2; Protein-tyrosinephosphatase 4a2; Protein-tyrosine phosphatase of regeneratingliver 2; PRL-2; PRL2; PRL 2; TP4A2_HUMAN; BM 008; EC 3.1.3.48; HH 13; HH13; HH7 2; HU PP 1; HUPP 1; HUPP1; OV 1; OV1; phosphatase of regenerating liver 2; Protein tyrosine phosphatase 4a2; protein tyrosine phosphatase IVA; protein tyrosine phosphatase IVA2; Protein tyrosine phosphatase of regenerating liver 2; protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase type IVA member 2 isoform 1; protein tyrosine phosphatase type IVA, member 2; PTP (CAAXII); ptp IV1a; ptp IV1b; PTP4A; PTPCAAX2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 19kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PTP4A2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Subunit:
In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.
Subcellular Location:
Cell membrane. Early endosome. Cytoplasm.
Tissue Specificity:
Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.
Post-translational modifications:
Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
Similarity:
Belongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain.
Database links:Entrez Gene: 8073Human
Entrez Gene: 19244Mouse
Entrez Gene: 85237Rat
Omim: 601584Human
SwissProt: Q12974Human
SwissProt: O70274Mouse
SwissProt: Q6P9X4Rat
Unigene: 470477Human
Unigene: 193688Mouse
Unigene: 167750Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.