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货号： bs-2101R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2101R-PE-Cy7
- 英文名称
- Anti-TEM1/PE-Cy7
- 中文名称
- PE-Cy7标记的内涎蛋白/内皮唾液酸蛋白抗体
- 别 名
- Tumor endothelial marker 1 precursor; TEM 1; TEM-1; tumor endothelial marker 1; CD248; Endosialin; Tumor endothelial marker 1; CD164L1; MGC119478; MGC119479. CD164 sialomucin-like 1; CD248_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞凋亡 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 80kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TEM 1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The transmembrane glycoprotein Tumor endothelial marker 1 (TEM1) is highly expressed in tumor endothelial cells however it is barely detectable on normal endothelial cells. It is believed to play a role in tumor angiogenesis. It is expressed in stromal fibroblasts, metastatic hepatic lesions and during angiogenesis of corpus luteum formation and wound healing. TEM1 is being investigated as a potential target for cancer treatment.
Function:
May play a role in tumor angiogenesis.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable).
Tissue Specificity:
Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts.
Post-translational modifications:
O-glycosylated with sialylated oligosaccharides.
May be N-glycosylated.
Similarity:
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.Contains 1 Sushi (CCP/SCR) domain.
Database links:Entrez Gene: 57124Human
Entrez Gene: 70445Mouse
Entrez Gene: 293669Rat
Omim: 606064Human
SwissProt: Q9HCU0Human
SwissProt: Q91V98Mouse
Unigene: 195727Human
Unigene: 29597Mouse
Unigene: 38806Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内皮唾液酸蛋白（CD248）是近年发现的人类肿瘤标记物之一,在人类多种恶性肿瘤组织中异常高表达,内皮唾液酸蛋白对肿瘤细胞生长、血管生成、浸润及转移有重要作用。