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货号： bs-2510R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2510R-PE-Cy7
- 英文名称
- Anti-ZNF217/PE-Cy7
- 中文名称
- PE-Cy7标记的锌指蛋白217抗体
- 别 名
- zinc finger protein 217; ZABC 1; ZABC1; ZN 217; ZN217; ZNF 217; 4933431C08Rik; AW987152; Gm562; Zfp217; ZN217_HUMAN .
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 染色质和核信号 信号转导 转录调节因子 结合蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 115kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZNF217
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ZNF217 (Zinc-finger protein 217) is a Kruppel-like zinc-finger protein which functions as a transcriptional repressor protein and forms a complex with a number of proteins including CoREST, BHC110/LSD1, HDAC2 and CtBP1. ZNF217 has been shown to repress E-cadherin promoter activity. ZNF217 is overexpressed in a number of cancers including breast and ovarian. ZNF217 and its associated proteins have been implicated in a novel pathway that is involved in cancer progression.
Function:
Binds to the promoters of target genes and functions as epressor. Promotes cell proliferation and antagonizes cell death. romotes phosphorylation of AKT1 at Ser-473.
Subunit:
Component of a histone deacetylase complex that contains DAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone eacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, DM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and TF2I. Interacts with CTBP1 and CTBP2.
Subcellular Location:
Nucleus (Probable).
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 7 C2H2-type zinc fingers.
Database links:Entrez Gene: 7764 Human
Omim: 602967 Human
SwissProt: O75362 Human
Unigene: 155040 Human
Unigene: 711564 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.