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货号： bs-2509R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2509R-PE-Cy7
- 英文名称
- Anti-AIMP2/PE-Cy7
- 中文名称
- PE-Cy7标记的AIMP2抗体
- 别 名
- Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Aimp2; AA407136; AA407225; Aimp2(p38); JTV 1 protein; Jtv1; MGC30261; MGC36346; MGC36522; MGC37389; ARS interacting multi functional protein 2; Multisynthetase complex auxiliary component p38; P38; tRNA SYNTHETASE COFACTOR p38; PRO0992; Protein JTV 1; JTV-1; JTV1; P38; PRO0992; AIMP2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human AIMP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
P38 is a probable core protein of the multisynthetase complex that serves as a template for the assembly of the supramolecular structure. Mediates ubiquitination of FUBP1 and its degradation by the proteasome. P38 is also a cofactor of multi-ARS complex and also a substrate of parkin in neuronal cell.
Function:
Required for assembly and stability of the minoacyl-tRNA synthase complex. Mediates ubiquitination and egradation of FUBP1, a transcriptional activator of MYC, leading o MYC down-regulation which is required for aveolar type II cell ifferentiation. Blocks MDM2-mediated ubiquitination and egradation of p53/TP53. Functions as a proapoptotic factor.
Subunit:
Component of the aminoacyl-tRNA synthase complex which is omprised of a bifunctional glutamyl-prolyl-tRNA synthase, the onospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, rginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). nteracts in both its unphosphorylated and phosphorylated forms ith p53/TP53 (via N-terminus) in the nucleus following UV rradiation. Interacts (via N-terminus) with KARS and PARK2/parkin via first RING-type domain).
Subcellular Location:
Cytoplasm, cytosol (By similarity). Nucleus By similarity). Note=Following DNA damage, dissociates from the minoacyl-tRNA synthase complex and translocates from the cytoplasm o the nucleus (By similarity).
Post-translational modifications:
Phosphorylated on serine residues in response to UV rradiation (By similarity).
Ubiquitinated by PARK2, leading to its degradation by the roteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, llowing its accumulation which may contribute to neurodegeneration ssociated with Parkinson disease.
Similarity:
Contains 1 GST C-terminal domain.
Database links:Entrez Gene: 7965 Human
Entrez Gene: 231872 Mouse
Entrez Gene: 288480 Rat
Omim: 600859 Human
SwissProt: Q13155 Human
SwissProt: Q8R010 Mouse
SwissProt: Q32PX2 Rat
Unigene: 301613 Human
Unigene: 728827 Human
Unigene: 200499 Mouse
Unigene: 162097 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.