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货号： bs-2535R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2535R-PE-Cy7
- 英文名称
- Anti-TFPI/PE-Cy7
- 中文名称
- PE-Cy7标记的组织因子途径抑制剂抗体
- 别 名
- Tissue factor pathway inhibitor-1; convertin; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein associated coagulation inhibitor; TFI; TFPI 1; TFPI1; Tissue factor pathway inhibitor; TFPI1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 32kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TFPI
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TFPI is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins.
Function:
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Subcellular Location:
Isoform Alpha: Secreted.
Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity:
Mostly in endothelial cells.
Post-translational modifications:
O-glycosylated.
Similarity:
Contains 3 BPTI/Kunitz inhibitor domains.
Database links:Entrez Gene: 7035 Human
Entrez Gene: 21788 Mouse
Entrez Gene: 29436 Rat
Omim: 152310 Human
SwissProt: P10646 Human
SwissProt: O54819 Mouse
SwissProt: Q02445 Rat
Unigene: 516578 Human
Unigene: 124316 Mouse
Unigene: 447013 Mouse
Unigene: 15795 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组织因子途径抑制因子(tissue factor pathway in hibitor, TFPI)是组织因子凝血途径的主要抑制因子， 组织因子途径抑制因子在诸如动脉粥样硬化，血管再狭窄，弥漫性血管内凝血DIC等方面，有一定的研究价值。